Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi G\u00f6z Hastal\u0131klar\u0131 Anabilim K\u0131sm\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. \u00d6zlem Barut Selver\u2019in\u00a0y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc \u00fcstlendi\u011fi \u201cAmniyon Membran Ekstrakt\u0131n\u0131n Limbal Eksplant K\u00fclt\u00fcrdeki K\u00f6k H\u00fccre Oran\u0131na Tesirinin Transforme Edici B\u00fcy\u00fcme Fakt\u00f6r Beta Resept\u00f6r \u0130nhibisyonu ile Mod\u00fclasyonu\u201d projesi T\u00fcrkiye S\u0131hhat Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131 (T\u00dcSEB) taraf\u0131ndan desteklenmeye uygun bulundu.<\/p>\n
Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak proje y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Do\u00e7. Dr. \u00d6zlem Barut Selver\u2019i makam\u0131nda a\u011f\u0131rlayarak \u00e7al\u0131\u015fmalar\u0131nda muvaffakiyetler diledi. Rekt\u00f6r Prof. Dr. Budak, Ege \u00dcniversitesinin bilhassa s\u0131hhat alan\u0131nda k\u0131ymetli projelere imza att\u0131\u011f\u0131n\u0131, bu projelerin de ulusal ve milletleraras\u0131 arenada pek \u00e7ok yetkili kurulu\u015f taraf\u0131ndan desteklendi\u011fini vurgulad\u0131. \u00a0<\/p>\n
Proje hakk\u0131nda bilgi veren Do\u00e7. Dr. \u00d6zlem Barut Selver, \u201cBebek zar\u0131 olarak bilinen insan amniyon membran\u0131 (iAM); yang\u0131 bask\u0131lay\u0131c\u0131 ve yara d\u00fczg\u00fcnle\u015ftirici \u00f6zellikleri ile t\u0131pta bir\u00e7ok alanda yayg\u0131n kullan\u0131m\u0131 bulunan k\u0131ymetli bir dokudur. G\u00f6z Hastal\u0131klar\u0131nda, bilhassa a\u011f\u0131r kimyasal yan\u0131klar\u0131n tedavisinde ve g\u00fczelle\u015fmeyen \u00fclserlerde, yara d\u00fczg\u00fcnle\u015fmesini h\u0131zland\u0131rmak, yang\u0131y\u0131 bask\u0131lamak, enfeksiyonu \u00f6nlemek ve yer kaplay\u0131c\u0131 \u00f6zelli\u011finden faydalanmak hedefiyle uygulanan iAM, s\u0131kl\u0131kla kriyoprezervasyonla haz\u0131rland\u0131ktan sonra \u2018amniyon membran nakli\u2019 formunda kullan\u0131lmaktad\u0131r. Bu kullan\u0131m halinin, cerrahi gerektirmesi, istenilen m\u00fchlet kadar kullan\u0131lamamas\u0131 ve yar\u0131 opak yap\u0131s\u0131 nedeniyle objektif klinik m\u00fc\u015fahedenin yap\u0131lamamas\u0131 \u00fczere k\u0131s\u0131tl\u0131l\u0131klar\u0131 bulunmaktad\u0131r. Bu k\u0131s\u0131tl\u0131l\u0131klar\u0131 azaltmak ismine, amniyon membran ekstrakt\u0131n\u0131n (AME) haz\u0131rlanmas\u0131, uygun saklama \u015fartlar\u0131n\u0131n sa\u011flanmas\u0131 hedefiyle liyofilize edilmesi ve buradan hareketle oftalmik \u00e7\u00f6zeltisinin haz\u0131rlanarak klinik pratikte uygulanmas\u0131 fikri do\u011fmu\u015ftur. AME formu kullan\u0131m\u0131n\u0131n en b\u00fcy\u00fck avantaj\u0131, cerrahi te\u015febb\u00fcs gerektirmemesi, tedavi m\u00fchletince ok\u00fcler y\u00fczeyin objektif klinik m\u00fc\u015fahedesinin yap\u0131labilmesi, uygulama m\u00fcddeti boyunca y\u00fcksek ve sabit \u00f6l\u00e7\u00fcde b\u00fcy\u00fcme fakt\u00f6r\u00fc dayana\u011f\u0131 sa\u011flayabilmesi ve uzun bir raf \u00f6mr\u00fcne sahip olabilme potansiyelidir. G\u00f6rme i\u015flevinin g\u00fczel olabilmesi i\u00e7in, g\u00f6z y\u00fczeyinde bulunan saydam doku olan kornean\u0131n sa\u011fl\u0131kl\u0131 olmas\u0131 gerekmektedir. G\u00f6z y\u00fczeyi k\u00f6k h\u00fccreleri kornean\u0131n yenilenerek sa\u011fl\u0131kl\u0131 kalmas\u0131ndan sorumludur. Kimyasal yan\u0131klar \u00fczere durumlarla bu k\u00f6k h\u00fccrelerin hasarlanmas\u0131, k\u00f6k h\u00fccre yetmezli\u011fi ile geli\u015fen k\u00f6rl\u00fckle sonu\u00e7lanabilir. B\u00f6ylesi bir sorunda kaybedilen k\u00f6k h\u00fccrelerin yerine konmas\u0131 kritik k\u0131ymet ta\u015f\u0131r. Laboratuvarda bu k\u00f6k h\u00fccrelerin \u00e7o\u011falt\u0131lmas\u0131 ile ilgili t\u00fcm d\u00fcnyada uzun y\u0131llard\u0131r \u00e7al\u0131\u015fmalar s\u00fcrmektedir\u201d dedi.<\/p>\n
\u201c5 y\u0131ld\u0131r etkin olarak AME ile ilgili \u00e7al\u0131\u015fmaktay\u0131z\u201d<\/b><\/p>\n
Do\u00e7. Dr. Barut Selver, \u201cG\u00f6z y\u00fczey k\u00f6k h\u00fccreleri ile ilgili olarak 20 y\u0131ld\u0131r, AME ile ilgili olarak ise 5 y\u0131ld\u0131r etkin olarak \u00e7al\u0131\u015fmaktay\u0131z. Bu bahisler ile ilgili bir\u00e7ok T\u00dcB\u0130TAK ve T\u00dcSEB da d\u00e2hil olmak \u00fczere ulusal ve memleketler aras\u0131 proje tamamlad\u0131k. \u00c7al\u0131\u015fmalar\u0131m\u0131za 2021 y\u0131l\u0131nda Ege \u00dcniversitesi T\u0131p Fak\u00fcltesi i\u00e7inde kurdu\u011fumuz Ok\u00fcler Y\u00fczey Ara\u015ft\u0131rma Laboratuvar\u0131nda devam etmekteyiz. Bug\u00fcne kadar yapm\u0131\u015f oldu\u011fumuz \u00e7al\u0131\u015fmalarla gelmi\u015f oldu\u011fumuz noktada ise, AME i\u00e7eri\u011finde ba\u015fka b\u00fcy\u00fcme fakt\u00f6rlerine nazaran daha y\u00fcksek \u00f6l\u00e7\u00fcde Transforme edici b\u00fcy\u00fcme fakt\u00f6r\u00fc beta (TGF\u03b2) bulundu\u011funu g\u00f6zlemledik.\u00a0 T\u00dcSEB projemiz ile ortamdaki TGF\u03b2 resept\u00f6r inhibisyonunun, ok\u00fcler y\u00fczey k\u00f6k h\u00fccre k\u00fclt\u00fcr\u00fcnde, destekleyici olarak ek edilen ve y\u00fcksek \u00f6l\u00e7\u00fcde TGF\u03b2 i\u00e7eren AME\u2019nin k\u00f6k h\u00fccre art\u0131\u015f\u0131 sa\u011flama tesirine mod\u00fclasyonunu tan\u0131mlayaca\u011f\u0131z\u201d diye konu\u015ftu.<\/p>\n
Kaynak: (BYZHA) Beyaz Haber Ajans\u0131<\/p>\n","protected":false},"excerpt":{"rendered":"
Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak proje y\u00fcr\u00fct\u00fcc\u00fcs\u00fc Do\u00e7. Dr. \u00d6zlem Barut Selver\u2019i makam\u0131nda a\u011f\u0131rlayarak \u00e7al\u0131\u015fmalar\u0131nda muvaffakiyetler diledi.<\/p>\n","protected":false},"author":1,"featured_media":3596,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[208,1742,575,1743],"class_list":["post-3595","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-saglik","tag-goz","tag-kok-hucre","tag-proje","tag-yuzey"],"_links":{"self":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/3595"}],"collection":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=3595"}],"version-history":[{"count":1,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/3595\/revisions"}],"predecessor-version":[{"id":3597,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/3595\/revisions\/3597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/media\/3596"}],"wp:attachment":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=3595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=3595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=3595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}