{"id":7780,"date":"2024-09-16T16:24:06","date_gmt":"2024-09-16T13:24:06","guid":{"rendered":"https:\/\/yalovasondakika.com.tr\/?p=7780"},"modified":"2024-09-16T16:24:06","modified_gmt":"2024-09-16T13:24:06","slug":"egeli-bilim-ekibi-toksoplazmaya-karsi-mrna-asisi-gelistirecek","status":"publish","type":"post","link":"https:\/\/yalovasondakika.com.tr\/index.php\/2024\/09\/16\/egeli-bilim-ekibi-toksoplazmaya-karsi-mrna-asisi-gelistirecek\/","title":{"rendered":"Egeli bilim ekibi Toksoplazma’ya kar\u015f\u0131 mRNA a\u015f\u0131s\u0131 geli\u015ftirecek"},"content":{"rendered":"

Ege \u00dcniversitesi Fen Fak\u00fcltesi Biyoloji K\u0131sm\u0131 Molek\u00fcler Biyoloji Anabilim K\u0131sm\u0131 \u00d6\u011fretim \u00dcyesi Do\u00e7. Dr. H\u00fcseyin Can\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 \u201cToxoplasma gondii SAG1, MIC1, ROP6, GRA1, SRS9 ve SporoSAG mRNA a\u015f\u0131 transkriptlerini i\u00e7eren miks mRNA a\u015f\u0131s\u0131 yakla\u015f\u0131m\u0131 ile toksoplazmozise kar\u015f\u0131 kollay\u0131c\u0131 yeni jenerasyon biyoteknolojik a\u015f\u0131 geli\u015ftirilmesi\u201d ba\u015fl\u0131kl\u0131 proje, T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu (T\u00dcB\u0130TAK) taraf\u0131ndan desteklenmeye uygun bulundu. Proje ile bilhassa gebelerde ve ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 zay\u0131f insan ve hayvanlarda tehlikeli sonu\u00e7lar do\u011furabilen \u201cToksoplazma\u201d enfeksiyonuna kar\u015f\u0131 mRNA a\u015f\u0131s\u0131 geli\u015ftirme ama\u00e7lan\u0131yor.<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Proje grubunu makam\u0131nda a\u011f\u0131rlayarak tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak,\u201cK\u0131sa m\u00fcddet evvel t\u00fcm d\u00fcnyay\u0131 derinden etkileyen pandemi s\u00fcreci bizlere a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131n ne kadar de\u011ferli oldu\u011funu g\u00f6sterdi. Tam akreditasyona sahip ara\u015ft\u0131rma \u00fcniversitemiz akademisyenleri, multidipliner bir anlay\u0131\u015f ve i\u015f birli\u011fi ile \u00a0Toksoplazma enfeksiyonuna y\u00f6nelik a\u015f\u0131 geli\u015ftirecekler. Temel bilimler ve s\u0131hhat alanlar\u0131nda esasl\u0131 bir ge\u00e7mi\u015fi bulanan \u00fcniversitemiz b\u00fcnyesinde bu cins \u00e7al\u0131\u015fmalar\u0131n ger\u00e7ekle\u015ftirilmesi bizleri ziyadesiyle memnun ediyor. Bu pahal\u0131 \u00e7al\u0131\u015fmalar\u0131 i\u00e7in akademisyenlerimizi tebrik ediyor, \u00e7al\u0131\u015fmalar\u0131nda muvaffakiyetler diliyorum\u201d dedi.<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\u201cBu parazitle gayrette a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131na gereksinim var\u201d<\/span><\/b><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Projenin gayesini anlatan Do\u00e7. Dr. H\u00fcseyin Can, \u201cProjede, insan ve hayvanlar\u0131 enfekte ederek toksoplazmozise neden olan Toxoplasma gondii\u2019ye kar\u015f\u0131 mRNA a\u015f\u0131s\u0131 geli\u015ftirmeyi hedefliyoruz. D\u00fcnyada insan n\u00fcfusunun 3\u2019te 1\u2019inin bu parazit ile enfekte oldu\u011fu varsay\u0131m ediliyor. Toksoplazmozisli sa\u011fl\u0131kl\u0131 bireylerde ekseriyetle her hangi bir klinik belirti g\u00f6zlenmezken ba\u011f\u0131\u015f\u0131kl\u0131k sistemi zay\u0131flam\u0131\u015f olanlarda \u00f6nemli mevtle sonu\u00e7lanabilen durumlar ortaya \u00e7\u0131kabilmekte. Ayr\u0131yeten, hamilelik devrinde al\u0131nd\u0131\u011f\u0131nda fet\u00fcse ge\u00e7erek d\u00fc\u015f\u00fcklere ve do\u011fumsal anomalilere de neden olabilmekte. \u00d6b\u00fcr taraftan veterinerlik alan\u0131nda da s\u0131kl\u0131kla koyunlarda d\u00fc\u015f\u00fcklere sebep olarak \u00f6nemli ekonomik kay\u0131plara yol a\u00e7\u0131yor. \u0130nsanlarda ve hayvanlarda kronik enfeksiyona sebep olan doku kistlerinin tedavisine y\u00f6nelik aktif bir ilac\u0131n olmamas\u0131 sebebiyle bu parazitle \u00e7abada a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131na gereksinim var. G\u00fcn\u00fcm\u00fczde yaln\u0131zca koyunlarda kullan\u0131m\u0131 ruhsatland\u0131r\u0131lm\u0131\u015f Toxovax a\u015f\u0131s\u0131n\u0131n var olmas\u0131, toksoplasmozise kar\u015f\u0131 faal a\u015f\u0131 geli\u015ftirilebilece\u011fini g\u00f6steriyor\u201d dedi.<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

\u00a0\u00a0\u00a0 \u201cmRNA a\u015f\u0131 teknolojisinin parazitler i\u00e7in kullan\u0131labilece\u011fi g\u00f6sterilecek\u201d<\/span><\/b><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

mRNA a\u015f\u0131lar\u0131n\u0131n koronavir\u00fcs pandemisinde muvaffakiyetle uyguland\u0131\u011f\u0131n\u0131 lisana getiren Do\u00e7. Dr. Can, \u201cG\u00fcn\u00fcm\u00fczde COVID-19 pandemisine kar\u015f\u0131 kullan\u0131lan \u2018mRNA a\u015f\u0131 platformu\u2019 geni\u015f kitlelere ba\u015far\u0131l\u0131 bir bi\u00e7imde uygulanm\u0131\u015ft\u0131r. Bu sebeple de \u00f6teki bula\u015f\u0131c\u0131 patojenlere kar\u015f\u0131 muvaffakiyetinin s\u00fcratlice test edilece\u011fi a\u00e7\u0131kt\u0131r. Projemiz kapsam\u0131nda \u2018Toxoplasma gondii\u2019ye kar\u015f\u0131 multivalan mRNA a\u015f\u0131s\u0131 geli\u015ftirilmesi\u2019 planlanm\u0131\u015ft\u0131r. Buna ba\u011fl\u0131 olarak projede Toxoplasma gondii SAG1, MIC1, ROP6, GRA1, SRS9 ve SporoSAG proteinlerini sentezleyen mRNA a\u015f\u0131 transkriptleri \u00fcretilecek ve lipit nanopartik\u00fclleri (LNP) ile form\u00fcle edilip farelere mRNA-LNP a\u015f\u0131s\u0131 uygulanacakt\u0131r. Daha sonra, a\u015f\u0131lanm\u0131\u015f fareler Toxoplasma gondii doku kistleri ile enfekte edilerek mRNA-LNP a\u015f\u0131s\u0131n\u0131n\u00a0 koruyuculu\u011fu g\u00f6sterilecektir. Sonu\u00e7 olarak; hem be\u015ferler hem de \u00e7iftlik hayvanlar\u0131 i\u00e7in k\u0131ymetli bir parazit olan Toxoplasma gondii\u2019ye kar\u015f\u0131 mRNA-LNP a\u015f\u0131s\u0131n\u0131n\u00a0 aktifli\u011fi deney hayvanlar\u0131nda test edilecektir. Dahas\u0131, bu proje ile birlikte COVID-19\u2019a kar\u015f\u0131 ba\u015far\u0131l\u0131 olan mRNA a\u015f\u0131lar\u0131n\u0131n yaln\u0131zca vir\u00fcslere kar\u015f\u0131 de\u011fil insanlarda salg\u0131nlara neden olabilecek parazitler i\u00e7in de kullan\u0131labilece\u011fi g\u00f6sterilmi\u015f olacak\u201d diye konu\u015ftu.<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Do\u00e7. Dr. H\u00fcseyin Can\u2019\u0131n y\u00fcr\u00fct\u00fcc\u00fcl\u00fc\u011f\u00fcn\u00fc yapt\u0131\u011f\u0131 projede, E\u00dc Fen Fak\u00fcltesi Molek\u00fcler Biyoloji Anabilim Kolu \u00d6\u011fretim \u00dcyesi Prof. Dr. Cemal \u00dcn, \u00a0E\u00dc A\u015f\u0131 Geli\u015ftirme Uygulama ve Ara\u015ft\u0131rma Merkezi \u00d6\u011fretim \u00dcyeleri; Prof. Dr. Y\u00fcksel G\u00fcr\u00fcz, Prof. Dr. Mert D\u00f6\u015fkaya, Do\u00e7. Dr. Aysu De\u011firmenci D\u00f6\u015fkaya, Do\u00e7. Dr. Hasan Akbaba, Do\u00e7. Dr. Muhammet Karakavuk ve Dr. \u00d6zlem G\u00fcnay E\u015fiyok yer al\u0131yor. \u00a0<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Kaynak: (BYZHA) Beyaz Haber Ajans\u0131<\/p>\n","protected":false},"excerpt":{"rendered":"

Proje tak\u0131m\u0131n\u0131 makam\u0131nda a\u011f\u0131rlayarak tebrik eden Ege \u00dcniversitesi Rekt\u00f6r\u00fc Prof. Dr. Necdet Budak,\u201cK\u0131sa m\u00fchlet evvel t\u00fcm d\u00fcnyay\u0131 derinden etkileyen pandemi s\u00fcreci bizlere a\u015f\u0131 \u00e7al\u0131\u015fmalar\u0131n\u0131n ne kadar de\u011ferli oldu\u011funu g\u00f6sterdi.<\/p>\n","protected":false},"author":1,"featured_media":7781,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[1733,811,2952,2953,575],"class_list":["post-7780","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gundem","tag-asi","tag-insan","tag-mrna-asi","tag-parazit","tag-proje"],"_links":{"self":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/7780"}],"collection":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=7780"}],"version-history":[{"count":1,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/7780\/revisions"}],"predecessor-version":[{"id":7782,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/7780\/revisions\/7782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/media\/7781"}],"wp:attachment":[{"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=7780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=7780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/yalovasondakika.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=7780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}